Myasthenia gravis: Antikörpertests – Diagnose
Über den Vortrag
Der Vortrag „Myasthenia gravis: Antikörpertests – Diagnose“ von Roy Strowd, MD ist Bestandteil des Kurses „Störungen der neuromuskulären Verbindungsstelle“.
Quiz zum Vortrag
Which of the following best describes the pathology that results from the AChR binding antibodies in myasthenia gravis?
- Attachment of anti-AChR antibodies to the AChR leads to complement activation and ultimate endocytosis and degradation of AChR.
- Antibodies act as competitive antagonists to the post-synaptic AChR.
- Antibodies lead to signal-induced down-regulation of protein expression.
- Cross-linking of AChR after antibody binding leads to internalization of the AChR in a complement independent manner.
- Binding AChR antibodies enter the synaptic cleft and act as competitive agonists to the post-synaptic AChR.
Which of the following actions describes the action of the anti-AChR blocking Ab?
- Impairs binding of ACh, leading to poor muscle contraction
- Cross-linking of AChR leading to complement activation and degradation of receptors
- Antigenic modulation occurs, leading to receptor endocytosis.
- Acetylcholinesterase is inhibited.
- The anti-AChR blocking Ab acts an indirect agonist on the AChR.
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Dozent des Vortrages Myasthenia gravis: Antikörpertests – Diagnose
Roy Strowd, MD
Dr. Roy Strowd is the Assistant Dean of Undergraduate Medical Education at the Wake Forest Baptist Medical Center, in North Carolina, USA.
He obtained his MD from Wake Forest School of Medicine in 2009, and his MEd from Johns Hopkins University in 2021. Currently, he co-directs the Neurofibromatosis and Tuberous Sclerosis Clinics at Wake Forest Baptist Medical Center, and is a researcher for the Adult Brain Tumor Consortium (ABTC) and Alliance for Clinical Trials in Neuro-Oncology.
Due to his achievements, he earned the M. Brownell Anderson Award from the Association of American Medical Colleges.
Within Lecturio, Dr. Strowd teaches courses on Clinical Neurology.
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