Pathophysiology and Clinical Manifestations – Calcific Aortic Stenosis
Über den Vortrag
Der Vortrag „Pathophysiology and Clinical Manifestations – Calcific Aortic Stenosis“ von Richard Mitchell, MD, PhD ist Bestandteil des Kurses „Valvular and Hypertensive Heart Disease“.
Quiz zum Vortrag
Which of the following risk factors is NOT related to calcific valvular degeneration?
- Elevated serum calcium levels
- Hyperlipidemia
- Hypertension
- Inflammation
- Smoking
Which aspect of the aortic valve system is typically affected by calcific degeneration?
- Outflow surface of the aortic valve
- The inner (ventricular) surface of the aortic valve
- Lunula (free edge) of the aortic valve
- Wall of the proximal aorta
- All surfaces of the aortic valve
Which of the following statements about patients with bicuspid aortic valves is TRUE?
- Stenosis due to calcifications occurs 1–2 decades earlier than in those with normal aortic valves.
- It occurs in 5%–10% of the population.
- Stenosis typically occurs during the seventh to ninth decades of life.
- It is not associated with the NOTCH1 genetic mutation.
- It is more commonly found in women.
At what aortic valve orifice diameter do most patients become symptomatic from calcific aortic stenosis?
- 0.5–1 cm²
- 4 cm²
- 0.1 cm²
- 8 cm²
- 2 cm²
What three conditions or symptoms are associated with increased mortality within 2–5 years in patients with calcific aortic stenosis?
- Syncope, angina, congestive heart failure
- Angina, syncope, pulmonary hypertension
- Pulmonary hypertension, diabetes, syncope
- Angina, endocarditis, arrhythmia
- Arrhythmia, syncope, congestive heart failure
What is the current treatment for symptomatic calcific aortic valve stenosis?
- Surgical valve replacement
- Diuretics
- ACE-inhibitors/ARBs
- Heart transplant
- Calcium channel blockers
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Dozent des Vortrages Pathophysiology and Clinical Manifestations – Calcific Aortic Stenosis
Richard Mitchell, MD, PhD
Dr. Richard N. Mitchell is the Lawrence J. Henderson Professor of Pathology and Health Sciences and Technology, at Harvard Medical School in Massachusetts, USA.
He obtained his PhD in Cell Biology and Immunology from Rockefeller University in 1980, and his MD from Harvard Medical School in 1984. Currently, he is Program Director of the Health Sciences and Technology Education and Curriculum at Harvard Medical School.
Due to his achievements, he earned the ASIP Robbins Distinguished Educator Award in 2013.
Within Lecturio, Dr. Mitchell teaches courses on Pathology.
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