COVID-19: Pathogenesis
Über den Vortrag
Der Vortrag „COVID-19: Pathogenesis“ von Sean Elliott, MD ist Bestandteil des Kurses „Year 4 – Selective Sub-Internship“.
Quiz zum Vortrag
How does the SARS-CoV-2 virus enter the host cell via membrane fusion?
- Proteolytic cleavage of the viral S protein permits fusion of the virus to the host cell membrane, leading to internalization of the virus.
- Viral proteases cleave the ACE-2 receptor, leading to the internalization of the virus into the host cell.
- Phages attach to receptors on the host cell and insert the viral genome.
- The viral genome is injected into the host cell after binding to the surface M protein.
- The viral envelope protein binds to the ACE-2 receptor and proteolytic cleavage leads to internalization of the virus.
What type of cells most abundantly express ACE-2 receptors in the body?
- Type II pneumocytes
- Skin epithelial cells
- Nasal mucosal epithelium
- Vascular endothelium
- GI tract cells
After the SARS-CoV-2 virus binds to the cell and is internalized, what is the host immune response to infection?
- Cytokine release of interleukins, interferons, and tumor necrosis factors
- Release of angiotensin-converting enzyme
- Activation of renin-angiotensin system
- Production of antibodies by T cells
- Production of memory cells to the antigen-presenting cell by T helper cells
After infection with SARS-CoV-2, what happens in response to the cytokine storm?
- Leakage of fluid into the alveolus disrupts gas exchange, causing respiratory symptoms.
- Blood pressure drops in response to ACE inhibition.
- Blood pressure drops in response to activation of the renin-angiotensin-aldosterone system.
- Cytokines cause improved gas exchange in the alveolus in response to respiratory distress.
- Cytokines stimulate the recruitment of immune cells to the respiratory system to help fight the infection.
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Dozent des Vortrages COVID-19: Pathogenesis
Sean Elliott, MD
Dr. Sean Elliott is the Professor of Clinical Pediatrics and the Associate Chair for the Department of Pediatrics at The University of Arizona, USA.
He obtained his MD from Columbia University College of Physicians and Surgeons in 1993. Currently, he is Pediatric Infectious Disease Specialist at the University of Arizona Medical Center.
He devotes time to Quality Improvement, graduate medical education efficacy and his scholarship with the Tucson Hospitals Medical Education Program (THMEP).
Within Lecturio, Dr. Elliott teaches courses on Microbiology.
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