C. Difficile Infection (Antibiotics)
Über den Vortrag
Der Vortrag „C. Difficile Infection (Antibiotics)“ von John Fisher, MD ist Bestandteil des Kurses „Year 3 – Internal Medicine“.
Quiz zum Vortrag
Which of the following antibiotics is LEAST likely to be the cause of antibiotic-associated colitis?
- Vancomycin
- Ampicillin
- Amoxicillin
- Clindamycin
- Trimethoprim
A patient has a second relapse of C. difficile colitis due to spore formation. What is the appropriate treatment?
- Pulsed regimen of oral vancomycin
- High dose intravenous vancomycin
- Intravenous metronidazole
- Oral metronidazole
- Oral metronidazole plus rectal vancomycin
How is C. difficile transmitted?
- Fecal-oral route
- C. difficile is not contagious, it is only due to antimicrobial treatment
- Through aspiration of spores
- Through ingestion of contaminated foods
- Typically spread through surgical instrumentation
Which C. difficile toxin is the most potent?
- Tcd B
- Tcd A
- Subunit C
- Binery Toxin
- CDT
How does the C. difficile toxin affect cells of the colon?
- Enters the cytoplasm and glycosylates RhoB protein which disrupts the actin cytoskeleton and kills the cell
- Binds to GM1 ganglioside on the mucosal cell surface and enters the endoplasmic reticulum
- Binds to Rho B protein then creates a pore in the cell wall and allows the active toxin to enter the cytoplasm
- Enters the cytoplasm and increases the production of cyclic AMP which causes ion transport abnormalities
- Enters the cytoplasm and is transported into the mitochondria through RhoB receptors which promotes an inflammatory response and cellular apoptosis
How is the diagnosis of C. difficile colitis typically confirmed?
- Enzyme immunoassay of 2 stool specimens
- It is simply a clinical diagnosis
- Serum analysis for C. difficile toxin A
- It can only be confirmed by pseudomembrane biopsy
- Stool cultures
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Dozent des Vortrages C. Difficile Infection (Antibiotics)
John Fisher, MD
Dr. John F. Fisher is a Professor of Medicine and Infectious Diseases at the Medical College of Georgia, Augusta University in the USA.
He obtained his medical degree from Virginia Commonwealth University School of Medicine in 1969. He is a Master of the American College of Physicians (MACP) and is certified by the American Board of Internal Medicine in Medicine and Infectious Diseases.
Due to his achievements, he has earned the Annual J. Willis Hurst Teaching Award, the Jane F. Deforges Excellence in Medical Education Award, and the Infectious Diseases Society of America's Clinical Teacher Award.
Within Lecturio, Dr. Fisher teaches courses on Infectious Diseases.
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